backdoor.poebot ON MY COMPUTER PLZ HELP OMG OMG PLZ HELP!?

backdoor.poebot.o was found on my computer by avg. it has a max risk level and said it could even crash my computer. My computer went crazy then ad aware found it too. i removed it and it repliciated itself. now it keeps saying 43ey.exe hs stopped working. it said backdoor.poebot.o Can even crash my computer. and it keeps trying to mess up my registry.

i have spybot search and destroy
malwarebytes
hijackthis
adaware
superantispyware
avg anti spyware
avg anti virus
spyware blaster
spyware guard.

Etc LOL. how did this Nasty get through my computer? it also said it will effect the rest of my network and It detects it in my system32 folder it has repliciated about 15 times now. any help? Thanks
what do ya know. spybot just found it and identified it as 3 trojans in my registry code named Win32.Iksmas.ai

once again. another Thing failed to remove this threat. It wont budge
oh joy. superantispyware found it as trojan.agent/gen-FXSTALLER

boot into safe mode disable system restore And Run your scans again and remove infections found

How to Remove a Virus, Malware, Trojans and hacks from your PC Part 2